On the cover: Technologies and creative methods are essential for research. They allow us to uncover new aspects of ourselves and our surrounding world and address what would otherwise be insurmountable problems. In this special issue, we explore how recently developed tools can be used to advance biological and bioengineering research and highlight the unmet needs that future tools must address. We hope this special issue creates inspiration for technologies that—like a friendly robot—lift us higher, move us faster, and carry us over obstacles to help us achieve the impossible.